JOURNAL OF RECENT ADVANCES IN APPLIED SCIENCES
VOL 29(1-2),2014

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CONTENTS
 

1.JOURNAL OF RECENT ADVANCES IN APPLIED SCIENCES(JRAAS) , 29:01-08, 2014, ISSN 0970 1990, ST CODE 08 ,www.jraas.org.E MAIL: mhcdr@rediff.com   DISPLAYED ON LINE MAY 2013                                               

Glutamine Intervention In Obstructive Jaundice Patients Performed With ERCP

Awasthi I1* , Kacker LK1, Natu SM2 , Singh S3, and  Siraj P4

1Department Of Surgical Gastroenterology, CSMMU, Lucknow.,2Department Of Pathology, CSMMU, Lucknow.,3Department of General Surgery, GSVM Medical College, Kanpur.,4Department Of Community Medicine And Public Health, CSMMU, Lucknow,*Email : induja.awasthi@gmail.com

ABSTRACT
Background: Carcinoma of the Gallbladder is an aggressive malignancy that occurs predominantly in the elderly. It is the most common form of biliary malignancy and the third most common carcinoma of the digestive tract in Eastern UP and Western Bihar. Present study has found trends to suggest that parenteral and enteral glutamine supplementation improves the nutritional status, quality of life and increasing the duration of survival in post ERCP obstructive jaundice patients.

Objective: Assessment of BMI, Quality Of Life and duration of survival in Glutamine supplemented post ERCP obstructive jaundice patients (50).

Methods: Glutamine supplementation was 50 ml (20g) / day intravenously for 3 days and 30g / day of Glutamine enterally for 4 days. Its effect was assessed on 42nd post ERCP day. BMI was used for determining Nutritional status and Karnofsky score was used for determining the Quality of life.

Result: In the study group,60% of the patients were female. Majority of the patients were in between 41-50 yrs of age (24%). All the patients improved from malnourished status to normal after supplementation. The quality of life of patients improved after Glutamine supplementation. After supplementation all the patients had their Karnofsky score above 50%.After Glutamine supplementation and ERCP, 88% of the patients survived for more than 42 days.
Conclusion: In the study it was found that Glutamine helps in improving the Nutritional Status, Quality of Life and increasing the duration of survival of Obstructive jaundice patients.

KEY WORDS: Glutamine, obstructive jaundice, BMI, Karnofsky Score.

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2.JOURNAL OF RECENT ADVANCES IN APPLIED SCIENCES(JRAAS)29:07-12, 2014,ISSN 0970 1990, ST CODE 08 ,www.jraas.org.E MAIL: mhcdr@rediff.com   DISPLAYED ON LINE MAY 2013                                                                           

Serum level of matrix metalloproteinase-3 in idiopathic Parkinson’s  disease patients

Vineeta Gupta1, Manish Kumar Singh1,  Ravindra Kumar Garg2, Rajesh Verma2, Kamlesh Kumar Pant1, Girdhar Gopal Agarwal3, Sanjay Khattri14

1Department of Pharmacology & Therapeutics, CSM Medical University, Lucknow, Uttar Pradesh, India. Department of Neurology, CSM Medical University, Lucknow, Uttar Pradesh, India. 3Department of Statistics, Lucknow University, Lucknow, India.
*Corresponding author: E-mail address: pharmacsmmu@gmail.com;  Tel.: +91 9415015700; Fax: +91 522 2257448

ABSTRACT
Background: Due to the lack of definitive biomarkers, Parkinson’s disease (PD) sometime becomes difficult to diagnose specially in early stages. Till date, its diagnosis is based on neurological examination. So, there is an unmet need to find out specific biomarkers. The matrix metalloproteinase-3 (MMP-3) found in the peripheral blood system may be involved in the pathophysiology of PD. The objective of the present study was to measure the level of serum MMP-3 in PD patients and controls.
Method: Case-control study was designed to assess the level of serum MMP-3 in 59 idiopathic PD patients (early PD=45, late PD=14) and compared with 16 neurologically healthy controls. The level of serum MMP-3 was examined and quantified using ELISA.
Results: The mean age of PD patients (early PD+late PD) was 56.78 years and controls was 53.44 years. Majority of the participants were male (early PD, late PD, Control: 73.3%, 85.7%, 68.8% respectively). The serum level of MMP-3 in Parkinson’s patients (early PD= 74.38+6.84 ng/ml, late PD= 70.35+9.64 ng/ml) was significantly (p<0.0001) elevated in comparison to controls (45.89 + 6.68 ng/ml).  Significantly poor correlation was found between the serum level of MMP-3 and age in all the groups (early PD r= 0.39, p<0.01; late PD r=-0.26, p>0.05; controls r= 0.18, p>0.05).
Conclusion: Our study demonstrated the increased level of serum MMP-3 in Parkinson’s patients that may provide clinical evidence for a supportive role of MMP-3 in the pathogenesis of Parkinson’s disease.

KEY WORDS: Parkinson’s disease, Early PD, Late PD, matrix metalloproteinase-

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3.JOURNAL OF RECENT ADVANCES IN APPLIED SCIENCES(JRAAS) 29,13-17,2014,ISSN 0970 1990, ST CODE 08 ,www.jraas.org.E MAIL: mhcdr@rediff.com   DISPLAYED ON LINE MAY 2013   

DEVELOPMENT AND STANDARDIZATION OF IRON RICH PAPAD MADE USING THREE FOOD GROUPS ENRICHED BY GREEN LEAFY VEGETABLE

SIRAJ P1*, AWASTHI I2

 1 Department of Community Medicine and Public Health, 2 Department of Surgical Gastroenterology, King George’s Medical University, Lucknow - 226003, U.P., India *Email: purnoorsiraj@gmail.com

ABSTRACT
Objective of the present study was to develop Iron rich papad, using three food groups (Cereal, Pulse & oil seed) and enriched with Green leafy vegetable (GLV), its Sensory evaluation and Iron estimation. The study was conducted withselection and processing of GLV, preparation of iron rich papad and its sensory evaluation. They were tested for different attributes (Taste, after taste, flavor, appearance, color, texture and overall acceptance). Estimation of iron content in processed GLV and most acceptable product was done by Acid Digestion method. Iron rich papad were prepared by using three food groups (Rice flakes, Soyabean and Niger seeds) and enriched by Cow pea leaves. Papads were prepared in three proportions of rice flakes: cow pea leavesviz code I (3:1), code II (4:0) and code III (2:1). Code I scored highest viz taste, flavor, appearance, color, overall acceptance and the differences were statistically significant (P<0.05). Iron content of processed cow pea leaves and iron rich papad was found to be 161mg/100g and 47.29mg/100g respectively. It was concluded that cow pea leaves is a good source of iron and its product “Iron Rich Papad” is highly acceptable.

KEY WORDS: Enrichment, Green leafy vegetables, Cow pea leaves, Iron rich papad, Sensory evaluation and Iron estimation.

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4.JOURNAL OF RECENT ADVANCES IN APPLIED SCIENCES(JRAAS) 29:18-21, 2014,ISSN 0970 1990, ST CODE 08 ,www.jraas.org.E MAIL: mhcdr@rediff.com   DISPLAYED ON LINE MAY 2013   

Association of non-alcoholic fatty liver disease with hepatic enzymes among adult population of north India

Pornoor Siraj1*, Neera Kohli1, VK Srivastava2, SM Natu3, Raj Mehrotra3, Kauser Usman4, Avinash Agarwal4, SK Singh2

1Department of Radiodiagnosis, 2Department of Community Medicine & Public Health,3Department of Pathology,4Department of Internal Medicine,King George’s Medical University, Lucknow, India *purnoorsiraj@gmail.com

ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) is a common clinical condition which is fast assuming importance as a possible precursor of more serious liver disorders, including cirrhosis of the liver and hepatocellular carcinoma. The present study was performed to assess the association of NAFLD with hepatic enzymes among north Indian subjects.  A sample of 76 subjects was taken for the present case-control study. For each case two healthy volunteers (age±3 years & gender matched) were selected. Study subjects includes patients who underwent USG examination of any part of the body and asymptomatic, apparently healthy attendants accompanying the patients were subjected to abdominal USG examination, individuals who gave a history of alcohol abuse were excluded from the study. Hepatic function tests included alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and serum bilirubin total were performed by standard laboratory procedures. Appropriate statistical methods were used for data analysis. The ALT was observed to be significantly (p<0.0001) higher among the subjects of NAFLD (42.55±16.02) as compared to controls (30.75±7.41). Similarly, AST (NAFLD=35.92±14.90, Controls=32.43±8.09; p=0.01) and ALP (NAFLD=271.97±66.23, Controls=141.36±49.95; p<0.0001) were also found to be significantly higher among NAFLD subjects as compared to controls. Whereas, no significant difference was seen in serum bilirubin total levels (NAFLD=0.92±0.16, Controls=0.89±0.20; p=0.15) among both groups. Conversely, results of multivariate logistic regression analysis shown that ALT (OR=2.34, 95%CI=1.12-4.56; p=0.03) and ALP (OR=1.03, 95%CI=10.02-1.04; p=0.04) were found to be significant risk factors for NAFLD. Hence it can be concluded that elevated ALT and ALP were the risk for NAFLD.

KEY WORDS: Nonalcoholic fatty liver disease, ultrasonography, hepatic function test, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, serum bilirubin total

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5.JOURNAL OF RECENT ADVANCES IN APPLIED SCIENCES(JRAAS) 29:22-27, 2014,ISSN 0970 1990, ST CODE 08 ,www.jraas.org.E MAIL: mhcdr@rediff.com   DISPLAYED ON LINE MAY 2013                                           

MARCHANTIA PALEACEA BERTOL. AS QUANTITATIVE BIOMONITOR OF ATMOSPHERIC HEAVY METALS DEPOSITION

VINAY SAHU*, VIRENDRA NATH*, A. K. ASTHANA* AND M. YUNUS**

Bryology Laboratory*, C.S.I.R.-National Botanical Research Institute,  Lucknow – 226 001, India
Department of Environmental Science**, BBA (Central) University, Lucknow, India)
Email: sahuvinay28@rediffmail.com

ABSTRACT
Bryophytes are known as good accumulators of heavy metals due to their simple morphological and physiological characteristics. The concentrations of five metals viz., Zn, Mn, Pb, Cu and Ni in Marchantia paleacea  Bertol. has been analyzed from different localities of Kumaon hills. The concentrations of the same elements were also determined in soil samples collected at the same sites to evaluate the role of soil as a potential source of metals uptake by the plant. Concentration of Pb, Cu, Ni and Zn was found higher in plant samples of disturbed sites as compared to less disturbed sites. Mn concentration was higher in soil samples as compared to plant samples. Correlation analysis (r) was also performed to investigate the relationship between the soil samples and accumulation of metal in the plant. Significant accumulation (P<0.01) of Pb, Cu and Ni was recorded at Bhowali taxi stand (Nainital). Present study revealed that the accumulation of toxic metals in M.  paleacea may be used in determining the air quality of the city and can be used for future biomonitoring studies.
KEY WORDS: Bryophytes, Heavy metals, Marchantia paleacea, Kumaon hills.

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6.JOURNAL OF RECENT ADVANCES IN APPLIED SCIENCES(JRAAS) 29:28-31, 2014,ISSN 0970 1990, ST CODE 08 ,www.jraas.org.E MAIL: mhcdr@rediff.com   DISPLAYED ON LINE MAY 2013                                                                             

IN-VITRO ANTIBACTERIAL ACTIVITY OF INDIGOFERA ARRECTA AGAINST SOME DRUG RESISTANT STRAINS OF SALMONELLA TYPHI AND METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS

EFUNTOYE, M.O*1, ASHIDI, J.S.2 AND ADEEKO, O.M.1

Department of Microbiology1, Department of Plant Science and Applied Zoology2,Olabisi Onabanjo University, P.M.B. 2002, Ago-Iwoye, Nigeria.
*Author for correspondence E-mail address: mosolatoye@yahoo.com

ABSTRACT
The present study investigates the antibacterial activity of the aqueous, hexane, methanol and ethanol extracts of the plant Indigofera arrecta using the agar well diffusion method. The extracts were tested against some strains of methicillin- resistant Staphylooccus aureus (MRSA) and Salmonella typhi. The plant showed the presence of phytochemical constituents such as tannins, saponins phenolic groups, flavonoids, triterpenes among others. The hexane extract showed the maximum inhibition against all the  strains of bacteria tested when compared with the other extracts. No activity was found with aqueous extract for MRSA strains tested while low activity was observed for strains of Salmonella typhi. The methanol and ethanol extracts showed moderate activity against the tested pathogens. The study suggests that leaves of Indigofera arrecta possess components with antimicrobial properties for production of natural antimicrobial drugs.

KEY WORDS: Indigofera arrecta, methicillin- resistant Staphylooccus aureus (MRSA) and Salmonella typhi

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7.JOURNAL OF RECENT ADVANCES IN APPLIED SCIENCES(JRAAS) 29:32-36, 2014,ISSN 0970 1990, ST CODE 08 ,www.jraas.org.E MAIL: mhcdr@rediff.com   DISPLAYED ON LINE MAY 2013      

CHEMOTAXONOMY OF EUPHORBIACEAE IN ANDHRA PRADESH, INDIA

A. Komuraiah*, A. Ragan and Vatsavaya  S. Raju

Plant Systematics Laboratory, Department of Botany, Kakatiya University, Warangal 506 009 (AP) India; Email: akbotany@ gmail.com.

ABSTRACT
Thirty species of  Euphorbiaceae pertaining to nine generas, viz. Breynia(3), Bridelia(2), Cleistanthus(1), Drypetes(1), Glochidion(1), Phyllanthus(17),  Sauropus(1), Securinega (2), Out Group(Givotia and Mallotus), are screened for aminoacids, and eight other secondary metabolites(alkaloids, ellagicacid, lignans, iridoids, methylinedioxy compounds, steroids, tannins and triterpenoids).There was positive reaction for alkaloids and negative to lignans, with all the species. The numerical relationships of taxa studied are discussed base on phenetic chemical evidence at specific generic levels.

KEY WORDS: Chemotaxonomy, Euphorbiaceae, Andhra Pradesh, India.

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8.JOURNAL OF RECENT ADVANCES IN APPLIED SCIENCES(JRAAS) 29:00-00,2014,ISSN 0970 1990, ST CODE 08 ,www.jraas.org.E MAIL: mhcdr@rediff.com   DISPLAYED ON LINE MAY 2013     

 

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9.JOURNAL OF RECENT ADVANCES IN APPLIED SCIENCES(JRAAS) 29:00-00,2014,ISSN 0970 1990, ST CODE 08 ,www.jraas.org.E MAIL: mhcdr@rediff.com   DISPLAYED ON LINE MAY 2013     

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